abstract：:While aging is generally associated with episodic memory decline, not all older adults exhibit memory loss. Furthermore, emotional memories are not subject to the same extent of forgetting and appear preserved in aging. We conducted high-resolution fMRI during a task involving pattern separation of emotional informati...

journal_title：Neurobiology of aging

authors： Leal SL,Noche JA,Murray EA,Yassa MA

更新日期：2017-01-01 00:00:00

abstract：:Cross-sectional studies show that elevated cerebral amyloid is associated with greater white-matter hyperintensity (WMH) burden in cognitively normal (CN) older adults. However, the relative time courses of amyloid and WMH accrual are unclear. To address this, we tested the associations between known WMH correlates-ag...

journal_title：Neurobiology of aging

authors： Scott JA,Braskie MN,Tosun D,Maillard P,Thompson PM,Weiner M,DeCarli C,Carmichael OT,ADNI.

更新日期：2016-12-01 00:00:00

abstract：:Possession of an Apolipoprotein E (APOE) e4 allele is an established risk factor for Alzheimer's disease, whereas the less commonly studied e2 variant is premised to offer some protection. This research explores the purported deleterious-protective dichotomy of APOE variants on attentional control in mid-adulthood. Si...

journal_title：Neurobiology of aging

authors： Lancaster C,Tabet N,Rusted J

更新日期：2016-12-01 00:00:00

abstract：:Aggregates of hyperphosphorylated tau protein are a pathological hallmark of Alzheimer's disease (AD). The origin of AD is multifactorial, and many metabolic disorders originating from overconsumption of fat, cholesterol, and sugar are associated with higher risk of AD later in life. However, the effects of fat, chole...

journal_title：Neurobiology of aging

authors： Gratuze M,Julien J,Morin F,Calon F,Hébert SS,Marette A,Planel E

更新日期：2016-11-01 00:00:00

abstract：:Deficits in synaptic structure and function are likely to underlie cognitive impairments in Alzheimer's disease. While synaptic deficits are commonly found in animal models of amyloidosis, it is unclear how amyloid pathology may impair synaptic functions. In some amyloid mouse models of Alzheimer's disease, however, s...

journal_title：Neurobiology of aging

authors： Cavanagh C,Tse YC,Nguyen HB,Krantic S,Breitner JC,Quirion R,Wong TP

更新日期：2016-11-01 00:00:00

abstract：:Mitochondrial ferritin (FtMt) is believed to play an antioxidant role via iron regulation, and FtMt gene mutation has been reported in age-related macular degeneration (AMD). However, little is known about FtMt's functions in the retina and any links to AMD. In this study, we observed age-related increase in FtMt and ...

journal_title：Neurobiology of aging

authors： Wang X,Yang H,Yanagisawa D,Bellier JP,Morino K,Zhao S,Liu P,Vigers P,Tooyama I

更新日期：2016-11-01 00:00:00

abstract：:Genetic factors have been suggested to be involved in the pathogenesis of sporadic inclusion body myositis (sIBM). Sequestosome 1 (SQSTM1) and valosin-containing protein (VCP) are 2 key genes associated with several neurodegenerative disorders but have yet to be thoroughly investigated in sIBM. A candidate gene analys...

journal_title：Neurobiology of aging

authors： Gang Q,Bettencourt C,Machado PM,Brady S,Holton JL,Pittman AM,Hughes D,Healy E,Parton M,Hilton-Jones D,Shieh PB,Needham M,Liang C,Zanoteli E,de Camargo LV,De Paepe B,De Bleecker J,Shaibani A,Ripolone M,Violano R,Mo

更新日期：2016-11-01 00:00:00

abstract：:We have analyzed the impact of Parkinson's disease (PD)-related genetic variants on splicing using dedicated minigene assays. Out of 14 putative splicing variants in 5 genes (PINK1, [PTEN induced kinase 1]; LRPPRC, [leucine-rich pentatricopeptide repeat containing protein]; TFAM, [mitochondrial transcription factor A]...

journal_title：Neurobiology of aging

authors： Gaweda-Walerych K,Mohagheghi F,Zekanowski C,Buratti E

更新日期：2016-11-01 00:00:00

abstract：:Genome-wide association studies (GWASs) have been effective approaches to dissect common genetic variability underlying complex diseases in a systematic and unbiased way. Recently, GWASs have led to the discovery of over 20 susceptibility loci for Alzheimer's disease (AD). Despite the evidence showing the contribution...

journal_title：Neurobiology of aging

authors： Sassi C,Nalls MA,Ridge PG,Gibbs JR,Ding J,Lupton MK,Troakes C,Lunnon K,Al-Sarraj S,Brown KS,Medway C,Clement N,Lord J,Turton J,Bras J,Almeida MR,ARUK Consortium.,Holstege H,Louwersheimer E,van der Flier WM,Schelte

更新日期：2016-10-01 00:00:00

abstract：:An individual's genetic makeup plays an important role in determining susceptibility to cognitive aging. Identifying the specific genes that contribute to cognitive aging may aid in early diagnosis of at-risk patients, as well as identify novel therapeutics targets to treat or prevent development of symptoms. Challeng...

journal_title：Neurobiology of aging

authors： Neuner SM,Garfinkel BP,Wilmott LA,Ignatowska-Jankowska BM,Citri A,Orly J,Lu L,Overall RW,Mulligan MK,Kempermann G,Williams RW,O'Connell KM,Kaczorowski CC

更新日期：2016-10-01 00:00:00

abstract：:The social species Octodon degus (degu) is the only wild-type South American rodent that develops Alzheimer's-like pathology with age. Here, we evaluated the ability of a natural product (Andrographolide, ANDRO), a diterpene of the labdane family obtained from the Asian plant Andrographis paniculata, to recover the co...

journal_title：Neurobiology of aging

authors： Rivera DS,Lindsay C,Codocedo JF,Morel I,Pinto C,Cisternas P,Bozinovic F,Inestrosa NC

更新日期：2016-10-01 00:00:00

abstract：:Although peripheral nerves are capable of regeneration, advanced age decreases the potential for functional recovery after injury. The cellular mechanisms for this are not currently understood. Here, we performed sciatic nerve grafting with young (2 months old) and aged (18 months old) Brown-Norway male rats, in which...

journal_title：Neurobiology of aging

authors： Scheib JL,Höke A

更新日期：2016-09-01 00:00:00

abstract：:Vascular risk factors (VRFs) increase the risk of Alzheimer's disease (AD) and contribute to neurodegenerative processes. The purpose of this study was to investigate whether increasing number of VRFs contributes to within-cohort differences in cortical thickness (CThk) among adults with mild cognitive impairment (MCI...

journal_title：Neurobiology of aging

authors： Tchistiakova E,MacIntosh BJ,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2016-09-01 00:00:00

abstract：:Aging-related episodic memory decline is often attributed to insufficient encoding of new information, although the underlying neural processes remain elusive. We here tested the hypothesis that impaired memory consolidation contributes to aging-related memory decline. To this end, we used resting state functional mag...

journal_title：Neurobiology of aging

authors： Kukolja J,Göreci DY,Onur ÖA,Riedl V,Fink GR

更新日期：2016-09-01 00:00:00

abstract：:Aging is accompanied by declines in memory performance, and particularly affects memories that rely on hippocampal-cortical systems, such as episodic and explicit. With aged populations significantly increasing, the need for preventing or rescuing memory deficits is pressing. However, effective treatments are lacking....

journal_title：Neurobiology of aging

authors： Steinmetz AB,Johnson SA,Iannitelli DE,Pollonini G,Alberini CM

更新日期：2016-08-01 00:00:00

abstract：:Diabetes may adversely affect cognitive function and, conversely, caloric restriction (CR) increases longevity and improves memory. To shed light on the unknown underlying mechanisms involved in these observations, we examined the effects of CR on serum metabolic parameters and hippocampal protein expression in the ob...

journal_title：Neurobiology of aging

authors： Jeon BT,Heo RW,Jeong EA,Yi CO,Lee JY,Kim KE,Kim H,Roh GS

更新日期：2016-08-01 00:00:00

abstract：:The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n = 539) and controls (n = 265) from New York, and PD patients (n = 551), rapid eye movement sleep behavior disorder (RBD) patients (n = 351), and controls (n = 956) of European ancestry. Sixty-eight MC1R vari...

journal_title：Neurobiology of aging

authors： Gan-Or Z,Mohsin N,Girard SL,Montplaisir JY,Ambalavanan A,Strong S,Mallett V,Laurent SB,Bourassa CV,Boivin M,Langlois M,Arnulf I,Högl B,Frauscher B,Monaca C,Desautels A,Gagnon JF,Postuma RB,Dion PA,Dauvilliers Y,Du

更新日期：2016-07-01 00:00:00

abstract：:Aging, amyloid deposition, and tau-related pathology are key contributors to the onset and progression of Alzheimer's disease (AD). However, AD is also associated with brain hypometabolism and deficits of mitochondrial bioenergetics. Plasma acylcarnitines (ACCs) are indirect indices of altered fatty acid beta-oxidatio...

journal_title：Neurobiology of aging

authors： Ciavardelli D,Piras F,Consalvo A,Rossi C,Zucchelli M,Di Ilio C,Frazzini V,Caltagirone C,Spalletta G,Sensi SL

更新日期：2016-07-01 00:00:00

abstract：:Advanced age is associated with a higher incidence of stroke and worse functional outcomes. Vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a potential method to improve recovery after brain injury but to date has only been evaluated in young rats. Here, we evaluated whether VNS paired...

journal_title：Neurobiology of aging

authors： Hays SA,Ruiz A,Bethea T,Khodaparast N,Carmel JB,Rennaker RL 2nd,Kilgard MP

更新日期：2016-07-01 00:00:00

abstract：:Mutants of presenilin 1 (PS1) increase neuronal cell death causing autosomal-dominant familial Alzheimer's disease (FAD). Recent literature shows that treatment of neuronal cultures with low concentrations of trypsin, a member of the serine family of proteases, protects neurons from toxic insults by binding to the pro...

journal_title：Neurobiology of aging

authors： Nikolakopoulou AM,Georgakopoulos A,Robakis NK

更新日期：2016-06-01 00:00:00

abstract：:Mutations in triggering receptor expressed on myeloid cells 2 (TREM2), which has been proposed to regulate the inflammatory responses and the clearance of apoptotic neurons and/or amyloid-β, are genetically linked to increased risk for late-onset Alzheimer's disease (AD). Interestingly, a missense variant in TREM-like...

journal_title：Neurobiology of aging

authors： Zheng H,Liu CC,Atagi Y,Chen XF,Jia L,Yang L,He W,Zhang X,Kang SS,Rosenberry TL,Fryer JD,Zhang YW,Xu H,Bu G

更新日期：2016-06-01 00:00:00

abstract：:Aging has been related to diminished cognitive function, which could be a result of ineffective synaptic function. We have previously shown that synaptic plasma membrane proteins supporting synaptic integrity and neurotransmission were downregulated in docosahexaenoic acid (DHA)-deprived brains, suggesting an importan...

journal_title：Neurobiology of aging

authors： Sidhu VK,Huang BX,Desai A,Kevala K,Kim HY

更新日期：2016-05-01 00:00:00

abstract：:Accumulating evidence suggests that engagement in leisure activities is associated with favorable trajectories of cognitive aging, but little is known about brain changes related to both activities and cognition. White matter microstructure shows experience-dependent plasticity and declines in aging. Therefore, we inv...

journal_title：Neurobiology of aging

authors： Köhncke Y,Laukka EJ,Brehmer Y,Kalpouzos G,Li TQ,Fratiglioni L,Bäckman L,Lövdén M

更新日期：2016-05-01 00:00:00

abstract：:The C9orf72 expansion is considered a major genetic cause of familial frontotemporal dementia (FTD) in several patients' cohorts. Interestingly, C9orf72 expansion carriers, present also abundant neuronal p62-positive inclusions. Although p62/SQSTM1 mutations were initially associated with Paget disease of bone (PDB), ...

journal_title：Neurobiology of aging

authors： Almeida MR,Letra L,Pires P,Santos A,Rebelo O,Guerreiro R,van der Zee J,Van Broeckhoven C,Santana I

更新日期：2016-04-01 00:00:00

abstract：:Pathologic expansion of the G4C2 repeat in C9orf72 is the main genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). To evaluate the frequency of the G4C2 expansion in a Latin American cohort of FTD and ALS patients, we used a 2-step genotyping strategy. For FTD, we observed an overal...

journal_title：Neurobiology of aging

authors： Itzcovich T,Xi Z,Martinetto H,Chrem-Méndez P,Russo MJ,de Ambrosi B,Uchitel OD,Nogués M,Silva E,Rojas G,Bagnatti P,Amengual A,Campos J,Rogaeva E,St George-Hyslop P,Allegri R,Sevlever G,Surace EI

更新日期：2016-04-01 00:00:00

abstract：:Evidence accumulates suggesting a complex interplay between neurodegenerative processes and serotonergic neurotransmission. We have previously reported an overexpression of serotonin 5-HT1A receptors (5-HT(1A)R) after intrahippocampal injections of amyloid-beta 1-40 (Aβ40) fibrils in rats. This serotonergic reactivity...

journal_title：Neurobiology of aging

authors： Verdurand M,Chauveau F,Daoust A,Morel AL,Bonnefoi F,Liger F,Bérod A,Zimmer L

更新日期：2016-04-01 00:00:00

abstract：:The impact of many inflammatory diseases is influenced by age-related changes in the activation of resident and circulating myeloid cells. In the eye, a major sight-threatening consequence of age-related macular degeneration is the development of severe choroidal neovascularization (CNV). To identify the molecular pat...

journal_title：Neurobiology of aging

authors： Robbie SJ,Georgiadis A,Barker SE,Duran Y,Smith AJ,Ali RR,Luhmann UFO,Bainbridge JW

更新日期：2016-04-01 00:00:00

abstract：:We investigated whether (1) serum levels of 25-hydroxyvitamin D [25(OH)D] and single nucleotide polymorphisms (SNPs) in the group-specific component (GC) gene-regulating serum 25(OH)D levels are associated with cognition in older individuals; and (2) whether causal relationships exist between 25(OH)D and cognition dur...

journal_title：Neurobiology of aging

authors： Kueider AM,Tanaka T,An Y,Kitner-Triolo MH,Palchamy E,Ferrucci L,Thambisetty M

更新日期：2016-03-01 00:00:00

abstract：:We identified and validated several novel inflammatory markers of cognitive performance in community-living older persons. An exploratory study (n = 83) correlated 177 inflammatory markers assayed by Luminex with the Mini-Mental State Examination (MMSE) and identified 8 inflammatory markers for enzyme-linked immunosor...

journal_title：Neurobiology of aging

authors： Gao Q,Camous X,Lu YX,Lim ML,Larbi A,Ng TP

更新日期：2016-03-01 00:00:00

abstract：:Progranulin (GRN) is a secreted growth factor involved in various cellular functions, and loss-of-function mutations are a major cause of frontotemporal lobar degeneration (FTLD) with TDP-43 positive pathology. Most FTLD-related GRN mutations are nonsense mutations resulting in reduced GRN expression. Nonsynonymous GR...

journal_title：Neurobiology of aging

authors： Kleinberger G,Capell A,Brouwers N,Fellerer K,Sleegers K,Cruts M,Van Broeckhoven C,Haass C

更新日期：2016-03-01 00:00:00

abstract：:Progranulin (PGRN) mutations account for an average of 15% of familial frontotemporal dementia (FTD) cases and 20% of total FTD cases worldwide. Here, we investigated the frequency of PGRN mutations in FTD patients (n = 116) from a clinical cohort of south India and detected one novel mutation located on exon 12 in a ...

journal_title：Neurobiology of aging

authors： Aswathy PM,Jairani PS,Raghavan SK,Verghese J,Gopala S,Srinivas P,Mathuranath PS

更新日期：2016-03-01 00:00:00

abstract：:In humans, action errors and perceptual novelty elicit activity in a shared frontostriatal brain network, allowing them to adapt their ongoing behavior to such unexpected action outcomes. Healthy and pathologic aging reduces the integrity of white matter pathways that connect individual hubs of such networks and can i...

journal_title：Neurobiology of aging

authors： Wessel JR,Ullsperger M,Obrig H,Villringer A,Quinque E,Schroeter ML,Bretschneider KJ,Arelin K,Roggenhofer E,Frisch S,Klein TA

更新日期：2016-02-01 00:00:00

abstract：:We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 ± 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar re...

journal_title：Neurobiology of aging

authors： Möller C,Hafkemeijer A,Pijnenburg YAL,Rombouts SARB,van der Grond J,Dopper E,van Swieten J,Versteeg A,Steenwijk MD,Barkhof F,Scheltens P,Vrenken H,van der Flier WM

更新日期：2016-02-01 00:00:00

abstract：:The neuroanatomical organization that underlies olfactory memory is different from that of other memory types. The present work examines olfactory memory in an elderly population-based sample (Swedish National Study on Aging and Care in Kungsholmen) aged 60-100 years (n = 2280). We used structural equation modeling to...

journal_title：Neurobiology of aging

authors： Larsson M,Hedner M,Papenberg G,Seubert J,Bäckman L,Laukka EJ

更新日期：2016-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by an extensive loss of motor neurons in the primary motor cortex, brainstem, and spinal cord. Genetic studies report a high heritability of ALS. Recently, whole-exome sequencing analysis of familial ALS (FALS) patients allow...

journal_title：Neurobiology of aging

authors： Leblond CS,Gan-Or Z,Spiegelman D,Laurent SB,Szuto A,Hodgkinson A,Dionne-Laporte A,Provencher P,de Carvalho M,Orrù S,Brunet D,Bouchard JP,Awadalla P,Dupré N,Dion PA,Rouleau GA

更新日期：2016-01-01 00:00:00

abstract：:Posterior cortical atrophy (PCA) is an understudied visual impairment syndrome most often due to "posterior Alzheimer's disease (AD)" pathology. Case studies detected mutations in PSEN1, PSEN2, GRN, MAPT, and PRNP in subjects with clinical PCA. To detect the frequency and spectrum of mutations in known dementia genes ...

journal_title：Neurobiology of aging

authors： Carrasquillo MM,Barber I,Lincoln SJ,Murray ME,Camsari GB,Khan QUA,Nguyen T,Ma L,Bisceglio GD,Crook JE,Younkin SG,Dickson DW,Boeve BF,Graff-Radford NR,Morgan K,Ertekin-Taner N

更新日期：2016-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease involving motor neurons. Because a growing number of genes have been identified as the genetic etiology of ALS, simultaneous screening of mutations in multiple genes is likely to be more efficient than gene-by-gene testing. In this ...

journal_title：Neurobiology of aging

authors： Kim HJ,Oh KW,Kwon MJ,Oh SI,Park JS,Kim YE,Choi BO,Lee S,Ki CS,Kim SH

更新日期：2016-01-01 00:00:00

abstract：:Genome-wide association studies have associated clusterin (CLU) variants with Alzheimer's disease (AD). However, the role of CLU on AD pathogenesis is not totally understood. We used cerebrospinal fluid (CSF) and plasma CLU levels as endophenotypes for genetic studies to understand the role of CLU in AD. CSF, but not ...

journal_title：Neurobiology of aging

authors： Deming Y,Xia J,Cai Y,Lord J,Holmans P,Bertelsen S,Holtzman D,Morris JC,Bales K,Pickering EH,Kauwe J,Goate A,Cruchaga C,Alzheimer's Disease Neuroimaging Initiative (ADNI).

更新日期：2016-01-01 00:00:00

abstract：:The objective of this study was to determine whether physiological fluctuations in white matter (PFWM) on resting-state functional magnetic resonance images could be used as an index of neurodegeneration and Alzheimer's disease (AD). Using resting-state functional magnetic resonance image data from participants in the...

journal_title：Neurobiology of aging

authors： Makedonov I,Chen JJ,Masellis M,MacIntosh BJ,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2016-01-01 00:00:00

abstract：:Clinico-pathological studies reveal that some elderly people with no cognitive impairment have high burdens of neurofibrillary tangles (NFTs), a pathology associated with Alzheimer's disease. We examined a total of 123 elderly participants without dementia and free of other neurological disorders or pathologies who at...

journal_title：Neurobiology of aging

authors： Mufson EJ,Malek-Ahmadi M,Perez SE,Chen K

更新日期：2016-01-01 00:00:00